Description

4-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-3-Iodo-5-Nitropyridine CAS NO 1186310-82-6 is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its core value lies in providing a protected pyrrolidine scaffold with orthogonal reactive sites (iodo and nitro groups), enabling precise and complex molecular construction. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides requiring sophisticated heterocyclic cores.
• Chemical Biology Probe Synthesis: Facilitates the creation of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Material Science: Serves as a building block for advanced organic electronic materials and functional polymers.
• Cross-Coupling Reactions: The iodo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Library Synthesis for Drug Discovery: Enables rapid generation of diverse compound libraries for high-throughput screening (HTS) campaigns.

Basic Information

Item	Detail
Product Name	4-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-3-Iodo-5-Nitropyridine
CAS No.	1186310-82-6
Molecular Formula	C16H26IN3O3Si
Molecular Weight	463.39 g/mol
Synonyms	3-Iodo-5-nitro-4-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-1-pyrrolidinyl]pyridine; 4-(3-((Tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-3-Iodo-5-Nitropyridine; TBS-protected pyrrolidinyl iodonitropyridine; 1-(3-Iodo-5-nitro-4-pyridinyl)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]pyrrolidine; 4-(3-((tert-Butyldimethylsilyloxy)methyl)-1-pyrrolidinyl)-3-iodo-5-nitropyridine
EINECS	Contact for details

Quality Control

Our 4-(3-((tert-Butyldimethylsilyloxy)Methyl)-Pyrrolidin-1-Yl)-3-Iodo-5-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.