Description

4-((tert-Butyldimethylsilyloxy)Methyl)-2-Chloro-3-(Dimethoxymethyl)Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a protected hydroxymethyl group and a reactive chloropyridine core. This compound is critical for enabling complex synthetic routes in medicinal chemistry, offering chemists a versatile and stable building block for constructing targeted molecular architectures. It is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its halogenated pyridine structure.
• Chemical Biology Probe Development: Serves as a precursor for creating labeled compounds or affinity probes used in target identification and validation studies.
• Material Science Research: Potential monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Academic & Contract Research: Essential reagent for methodology development and synthetic organic chemistry research in academic and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	4-((tert-Butyldimethylsilyloxy)Methyl)-2-Chloro-3-(Dimethoxymethyl)Pyridine
CAS No.	1186310-67-7
Molecular Formula	C15H26ClNO3Si
Molecular Weight	331.91 g/mol
Synonyms	2-Chloro-3-(dimethoxymethyl)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]pyridine; 2-Chloro-3-(dimethoxymethyl)-4-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; 4-(((Tert-Butyldimethylsilyl)oxy)methyl)-2-chloro-3-(dimethoxymethyl)pyridine; TBS-protected Chloropyridine Intermediate; 4-(TBDMS-O-Methyl)-2-Chloro-3-(Dimethoxymethyl)Pyridine
EINECS	Contact for details

Quality Control

Every batch of 4-((tert-Butyldimethylsilyloxy)Methyl)-2-Chloro-3-(Dimethoxymethyl)Pyridine is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for use in GMP (Good Manufacturing Practice) environments, and we provide full traceability and documentation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain product integrity and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.