Description

Methyl 2-(3-Ethylureido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinate is a high-purity, advanced pharmaceutical intermediate featuring a key boronic ester functional group. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Used in palladium-catalyzed reactions to form carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl scaffolds prevalent in drug molecules.
• Agrochemical Research: Intermediate in the development of new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science & OLED Development: Serves as a precursor for creating organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in OLED devices.
• Chemical Biology & Proteomics: Can be utilized in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for synthetic chemistry research in academic institutions and contract research organizations (CROs).

Basic Information

Product Name	Methyl 2-(3-Ethylureido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinate
CAS No.	1186113-73-4
Molecular Formula	C16H24BN3O5
Molecular Weight	349.19 g/mol
Synonyms	2-(3-Ethylureido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinic acid methyl ester; Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[(ethylcarbamoyl)amino]isonicotinate; 2-[(Ethylcarbamoyl)amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinic acid methyl ester; 5-(Pinacolatoboryl)-2-(3-ethylureido)isonicotinic acid methyl ester; Borylation Reagent 1186113-73-4; Suzuki Coupling Boronate Ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 2-(3-Ethylureido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening a new container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.