Description

α-[3-(1,1-Dimethylethoxy)-3-Oxopropyl]-ω-Hydroxypoly(Oxy-1,2-Ethanediyl) is a specialized functionalized polyethylene glycol (PEG) derivative, designed to act as a versatile linker or spacer molecule in advanced synthesis. This compound matters for its ability to introduce solubility, biocompatibility, and controlled reactivity into complex chemical architectures, enabling the development of high-performance materials and bioconjugates. It is essential for R&D and production teams in the pharmaceutical, biotechnology, and advanced materials sectors who require precise molecular tools for drug delivery systems, polymer modification, and surface functionalization.

Application

• Pharmaceutical Linker: Used in the synthesis of prodrugs and antibody-drug conjugates (ADCs) to connect active pharmaceutical ingredients (APIs) to targeting moieties.
• Polymer Modification: Serves as a functional initiator or terminator in the synthesis of block copolymers and PEGylated materials to enhance hydrophilicity and stealth properties.
• Surface Functionalization: Applied to modify nanoparticles, quantum dots, and diagnostic assay substrates to improve aqueous dispersion and reduce non-specific binding.
• Bioconjugation Reagent: Facilitates the stable attachment of peptides, proteins, or oligonucleotides to various carriers or solid supports.
• Crosslinking Agent: Employed in hydrogel formation and biomaterial fabrication where controlled degradation or swelling is required.
• Solubility Enhancer: Used to modify hydrophobic compounds, increasing their solubility for formulation in aqueous-based systems.

Basic Information

Product Name	α-[3-(1,1-Dimethylethoxy)-3-Oxopropyl]-ω-Hydroxypoly(Oxy-1,2-Ethanediyl)
CAS No.	1186025-29-5
Molecular Formula	CnH2n+2Om (Variable, PEG-based)
Molecular Weight	Variable (Depends on PEG chain length 'n')
Synonyms	3-(tert-Butoxy)-3-oxopropyl-PEG-OH; tert-Butyl 3-hydroxy-PEG-propanoate; ω-Hydroxy-PEG-β-tert-butoxypropionate; PEG-diester mono-tert-butyl ester; PEG-based tert-butyl ester monoalcohol; Boc-protected PEG acid monoalcohol derivative; Poly(ethylene glycol) mono(3-tert-butoxy-3-oxopropyl) ether
EINECS	Contact for details

Quality Control

Every batch of our α-[3-(1,1-Dimethylethoxy)-3-Oxopropyl]-ω-Hydroxypoly(Oxy-1,2-Ethanediyl) is manufactured under a quality management system and undergoes rigorous analytical testing. We ensure compliance with critical parameters for pharmaceutical and research applications, including purity, molecular weight distribution, and functional group integrity. Certificates of Analysis (COA) detailing batch-specific results from NMR, HPLC, and titration methods are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or waxy solid
Identification (IR)	Conforms to structure
Assay (Purity)	≥ 95.0% (by NMR/HPLC)
Average Molecular Weight (Mn)	As per customer grade (e.g., 1000, 2000, 5000 Da)
Polydispersity Index (PDI)	≤ 1.05 - 1.10 (by GPC)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Substitution	≥ 90% (by end-group analysis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.