Description

1-(2-Chloro-Thiazol-5-Ylmethyl)-Piperazine Dihydrochloride is a high-purity, functionalized piperazine derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and building block for the development of novel active ingredients. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antimicrobial therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the thiazole and piperazine motifs for biological activity.
• Chemical Biology & Proteomics: Serves as a versatile linker or functional handle in the design of chemical probes and bioconjugates.
• Material Science: Potential precursor for specialty polymers and functional materials requiring specific heterocyclic components.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.
• Academic & Industrial R&D: Fundamental research reagent for exploring new synthetic methodologies and reaction pathways.

Basic Information

Product Name	1-(2-Chloro-Thiazol-5-Ylmethyl)-Piperazine Dihydrochloride
CAS No.	1185312-01-9
Molecular Formula	C8H13ClN3S • 2HCl
Molecular Weight	307.09 g/mol (for dihydrochloride salt)
Synonyms	1-[(2-Chloro-1,3-thiazol-5-yl)methyl]piperazine dihydrochloride; 5-(Piperazin-1-ylmethyl)-2-chlorothiazole dihydrochloride; 2-Chloro-5-(piperazin-1-ylmethyl)thiazole dihydrochloride; 1-(2-Chlorothiazol-5-ylmethyl)piperazine dihydrochloride; 1-(2-Chloro-thiazol-5-yl-methyl)-piperazine dihydrochloride; 1185312-01-9
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-Thiazol-5-Ylmethyl)-Piperazine Dihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for pharmaceutical applications and can provide additional documentation as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.