Description

1-(2-Chloro-6-Fluorobenzyl)Piperidine-4-Carboxylic Acid Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1185295-60-6. This compound is a critical building block in modern medicinal chemistry, valued for its piperidine-carboxylic acid core and halogenated benzyl moiety, which are essential for developing bioactive molecules. It is primarily required by research institutions and pharmaceutical companies engaged in the synthesis of novel drug candidates, particularly in the areas of central nervous system (CNS) agents and receptor modulators.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic compounds.
• Ligand Synthesis: Serves as a core structure for creating high-affinity ligands for various G-protein coupled receptors (GPCRs).
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development.
• Reference Standard: Acts as a certified reference material for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	1-(2-Chloro-6-Fluorobenzyl)Piperidine-4-Carboxylic Acid Hydrochloride
CAS No.	1185295-60-6
Molecular Formula	C14H16ClFNO2·HCl
Molecular Weight	320.20 g/mol (Free base: 283.74 g/mol)
Synonyms	1-[(2-Chloro-6-fluorophenyl)methyl]piperidine-4-carboxylic acid hydrochloride; 4-Piperidinecarboxylic acid, 1-[(2-chloro-6-fluorophenyl)methyl]-, hydrochloride (1:1); 1-(2-Chloro-6-fluorobenzyl)-4-piperidinecarboxylic acid hydrochloride; 1185295-60-6; UNII-6V9Q8S2Q3F; 6V9Q8S2Q3F; SCHEMBL21806227; AKOS040759488
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-6-Fluorobenzyl)Piperidine-4-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.