Description

1-[4-Fluoro-2-(Methylsulfonyl)Phenyl]Homopiperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific fluorinated and sulfonated aromatic structure. This compound is of critical importance for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system and metabolic disorders. It is primarily required by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the synthesis of complex, small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially those with sulfone and piperazine pharmacophores.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Process Development & Scale-up: Serves as a critical raw material for process chemistry teams during route scouting, optimization, and pilot-scale manufacturing.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in API production.
• Contract Research & Manufacturing (CRAM): Supplied to organizations providing custom synthesis and development services for the global pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and pharmacological studies.

Basic Information

Product Name	1-[4-Fluoro-2-(Methylsulfonyl)Phenyl]Homopiperazine Hydrochloride
CAS No.	1185015-65-9
Molecular Formula	C12H16FN3O2S • HCl
Molecular Weight	321.80 g/mol (Free base: 285.34 g/mol)
Synonyms	1-[(4-Fluoro-2-methanesulfonyl)phenyl]hexahydro-1H-1,4-diazepine hydrochloride; 1-(4-Fluoro-2-methylsulfonylphenyl)homopiperazine hydrochloride; Homopiperazine, 1-[4-fluoro-2-(methylsulfonyl)phenyl]-, hydrochloride; 1-(4-Fluoro-2-methanesulfonylphenyl)homopiperazine HCl; 1-(4-Fluoro-2-(methylsulfonyl)phenyl)hexahydro-1H-1,4-diazepine hydrochloride; 1185015-65-9; 1-(4-Fluoro-2-methylsulfonyl-phenyl)-homopiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-[4-Fluoro-2-(Methylsulfonyl)Phenyl]Homopiperazine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if opened, and desiccate if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.