Description

4-[4-Amino-2-(Trifluoromethyl)Phenyl]-2-Piperazinone is a high-value, multi-functional heterocyclic building block featuring both an aromatic amine and a piperazinone moiety. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced materials due to its unique trifluoromethyl-substituted aromatic structure. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and lipophilicity.
• Material Science Research: Serves as a precursor for functional polymers and liquid crystals, leveraging its rigid aromatic core and hydrogen-bonding capabilities.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring complex, fluorinated heterocyclic architectures.

Basic Information

Product Name	4-[4-Amino-2-(Trifluoromethyl)Phenyl]-2-Piperazinone
CAS No.	1183065-10-2
Molecular Formula	C11H12F3N3O
Molecular Weight	259.23 g/mol
Synonyms	2-Piperazinone, 4-[4-amino-2-(trifluoromethyl)phenyl]-; 4-(4-Amino-2-trifluoromethylphenyl)-2-piperazinone; 4-(4-Amino-2-(trifluoromethyl)phenyl)piperazin-2-one; 1-(4-Amino-2-(trifluoromethyl)phenyl)piperazine-2,3-dione (tautomer); 1183065-10-2; 4-Amino-2-(trifluoromethyl)phenyl piperazinone; Trifluoromethyl aniline piperazinone derivative
EINECS	Contact for details

Quality Control

Our 4-[4-Amino-2-(Trifluoromethyl)Phenyl]-2-Piperazinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatograms and spectra are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.