Description

2-(Piperazin-1-Yl)-1-(Pyrrolidin-1-Yl)Ethanone Dihydrochloride is a high-purity organic salt, primarily utilized as a sophisticated pharmaceutical intermediate. Its value lies in its role as a key building block for synthesizing complex molecules, particularly in medicinal chemistry research and development. This compound is essential for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on developing new active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a key building block in the production route for complex APIs, especially those containing piperazine and pyrrolidine pharmacophores.
• Biochemical Research: Employed in the development of chemical probes and tool compounds for studying biological pathways and target validation.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for use in custom synthesis and scale-up projects under cGMP conditions.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	2-(Piperazin-1-Yl)-1-(Pyrrolidin-1-Yl)Ethanone Dihydrochloride
CAS No.	1182708-84-4
Molecular Formula	C10H20N3O·2HCl
Molecular Weight	279.21 g/mol (free base: 198.29 g/mol)
Synonyms	1-(1-Pyrrolidinyl)-2-(1-piperazinyl)ethanone dihydrochloride; 2-(Piperazin-1-yl)-1-(pyrrolidin-1-yl)ethan-1-one dihydrochloride; 1-Pyrrolidinyl 2-piperazinyl ketone dihydrochloride; 2-Piperazin-1-yl-1-pyrrolidin-1-yl-ethanone dihydrochloride; Ethanone, 2-(1-piperazinyl)-1-(1-pyrrolidinyl)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Piperazin-1-Yl)-1-(Pyrrolidin-1-Yl)Ethanone Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, residual solvents, and appearance are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%; Total impurities ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.