Description

tert-Butyl 3-thioxopiperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with a protected amine and a thioxo functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with potential therapeutic applications. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those containing piperazine or piperidine motifs.
• Protease Inhibitor Research: Serves as a precursor in the development of inhibitors targeting various proteases, which are relevant in virology and oncology.
• Kinase Inhibitor Development: Used in constructing heterocyclic scaffolds for potential kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Biology & Probe Synthesis: Employed in the creation of chemical probes for studying enzyme function and biological pathways.
• Peptidomimetic Chemistry: Acts as a constrained, non-peptide backbone element in the design of peptidomimetics to improve metabolic stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 3-thioxopiperazine-1-carboxylate
CAS No.	1182359-40-5
Molecular Formula	C9H16N2O2S
Molecular Weight	216.30 g/mol
Synonyms	1-Boc-3-thioxopiperazine; tert-Butyl 3-thioxo-1-piperazinecarboxylate; 3-Thioxopiperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-thioxopiperazine; Boc-3-thioxopiperazine; 1-N-Boc-3-thioxopiperazine; Piperazine-1-carboxylic acid, 3-thioxo-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-thioxopiperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and consistency for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.