Description

(3R,4R,4As,12Bs)-3-(Cyclopropylmethyl)-4A,9-Dihydroxy-3-Methyl-5,7-Dioxo-2,3,4,4A,5,6,7,7A-Octahydro-1H-4,12-Methanobenzofuro[3,2-E]Isoquinolin-3-Ium Bromide is a high-purity, complex organic salt of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analytical characterization of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on medicinal chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly in opioid receptor research.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in HPLC, LC-MS, and NMR to ensure batch-to-batch consistency.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize pharmacological profiles of new chemical entities.
• Process Chemistry Development: Serves as a model compound for scaling up synthetic routes and optimizing reaction conditions in pilot plants.
• Academic & Institutional Research: Used in university laboratories for cutting-edge research in organic synthesis and neuropharmacology.
• Impurity Standard: Critical for identifying and quantifying process-related impurities or degradation products in final drug substances.

Basic Information

Product Name	(3R,4R,4As,12Bs)-3-(Cyclopropylmethyl)-4A,9-Dihydroxy-3-Methyl-5,7-Dioxo-2,3,4,4A,5,6,7,7A-Octahydro-1H-4,12-Methanobenzofuro[3,2-E]Isoquinolin-3-Ium Bromide
CAS No.	1178899-11-0
Molecular Formula	C₂₁H₂₄BrNO₅
Molecular Weight	450.33 g/mol
Synonyms	Buprenorphine Impurity; Buprenorphine Related Compound; 3-Cyclopropylmethyl-4a,9-dihydroxy-3-methyl-5,7-dioxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium bromide; Buprenorphine Bromide Salt; BPN Impurity; (3R,4R,4aR,12bR)-3-(Cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-5,7-dioxo-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-3-ium bromide
EINECS	Contact for details

Quality Control

Our (3R,4R,4As,12Bs)-3-(Cyclopropylmethyl)-4A,9-Dihydroxy-3-Methyl-5,7-Dioxo-2,3,4,4A,5,6,7,7A-Octahydro-1H-4,12-Methanobenzofuro[3,2-E]Isoquinolin-3-Ium Bromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.