Description

2-Chloro-1-[4-(Thiophene-3-Carbonyl)-Piperazin-1-Yl]-Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core functionalized with a thiophene carbonyl group and a reactive chloroacetyl moiety. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates with potential activity in central nervous system and other therapeutic areas. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and biotechnology sectors for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small molecule drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• API Development: Serves as a building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and pharmacology projects.

Basic Information

Product Name	2-Chloro-1-[4-(Thiophene-3-Carbonyl)-Piperazin-1-Yl]-Ethanone
CAS No.	1178020-04-6
Molecular Formula	C11H11ClN2O2S
Molecular Weight	270.73 g/mol
Synonyms	1-(4-(Thiophene-3-carbonyl)piperazin-1-yl)-2-chloroethanone; 2-Chloro-1-(4-(3-thienylcarbonyl)-1-piperazinyl)ethanone; 2-Chloro-1-[4-(thiophene-3-carbonyl)piperazin-1-yl]ethanone; 2-Chloro-1-(4-(thiophene-3-carbonyl)piperazin-1-yl)ethanone; 1-(4-(3-Thiophenecarbonyl)-1-piperazinyl)-2-chloro-1-ethanone; Ethanone, 2-chloro-1-[4-(3-thienylcarbonyl)-1-piperazinyl]-; 1178020-04-6
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-[4-(Thiophene-3-Carbonyl)-Piperazin-1-Yl]-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.