Description

2-Bromo-5-(Methylsulfonyl)Pyrazine is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate, enabling the introduction of both bromo and methylsulfonyl functional groups for further cross-coupling and derivatization reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by specialty chemical manufacturers producing advanced materials and ligands.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in kinase inhibitor and other small molecule therapeutic programs.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials and functional polymers where the pyrazine core and substituents modify electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Library Production: A valuable building block for combinatorial chemistry and high-throughput screening libraries in drug discovery.

Basic Information

Product Name	2-Bromo-5-(Methylsulfonyl)Pyrazine
CAS No.	1177421-54-3
Molecular Formula	C5H5BrN2O2S
Molecular Weight	237.08 g/mol
Synonyms	2-Bromo-5-methanesulfonylpyrazine; 5-Bromo-2-(methylsulfonyl)pyrazine; Pyrazine, 2-bromo-5-(methylsulfonyl)-; 1177421-54-3; 2-Bromo-5-methylsulfonylpyrazine
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Methylsulfonyl)Pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP-compliant development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from moisture and direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.