Description

1-(Trifluoroacetyl)-1,4-Diazepane Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique diazepane core modified with a trifluoroacetyl group. This compound matters for its critical role as a versatile building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery. It is primarily needed by research institutions and pharmaceutical companies developing novel therapeutic agents, including potential candidates for central nervous system (CNS) and metabolic disorders.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those targeting neurological and psychiatric conditions.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The diazepane structure is valuable in the design and synthesis of protease enzyme inhibitors.
• Chemical Biology Probes: Employed in the development of chemical probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to the pharmaceutical and biotechnology industries.
• Academic Research: Utilized in university and institutional labs for methodological development and exploratory synthetic chemistry.

Basic Information

Product Name	1-(Trifluoroacetyl)-1,4-Diazepane Hydrochloride
CAS No.	1177329-26-8
Molecular Formula	C7H10F3N2O • HCl
Molecular Weight	232.62 g/mol
Synonyms	1,4-Diazepane, 1-(trifluoroacetyl)-, hydrochloride (1:1); 1-(Trifluoroacetyl)homopiperazine hydrochloride; 1-(2,2,2-Trifluoroacetyl)homopiperazine HCl; Homopiperazine, 1-(trifluoroacetyl)-, hydrochloride; 1,4-Diazepan-1-yl(trifluoro)methanone hydrochloride; 1-(1,4-Diazepan-1-yl)-2,2,2-trifluoroethanone hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Trifluoroacetyl)-1,4-Diazepane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications in GMP-compliant development and non-GMP research, ensuring reliable supply for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.