Description

(3As,6As)-5-Methyloctahydropyrrolo[3,4-B]Pyrrole CAS NO 1176846-84-6 is a high-purity, advanced pharmaceutical intermediate featuring a unique bicyclic pyrrolidine structure. This compound is of significant value in medicinal chemistry for its role as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas such as central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the synthesis of novel drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used as a versatile building block in structure-activity relationship (SAR) studies and lead optimization processes.
• Asymmetric Synthesis: Employed as a precursor or ligand in catalytic asymmetric reactions due to its defined stereochemistry.
• Protease Inhibitor Development: Acts as a core structural motif in the design and synthesis of potential protease inhibitors.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(3As,6As)-5-Methyloctahydropyrrolo[3,4-B]Pyrrole
CAS No.	1176846-84-6
Molecular Formula	C8H16N2
Molecular Weight	140.23 g/mol
Synonyms	5-Methyloctahydropyrrolo[3,4-b]pyrrole; (3aR,6aR)-5-Methylhexahydro-1H-pyrrolo[3,4-b]pyrrole; (3aR,6aR)-5-Methyloctahydropyrrolo[3,4-b]pyrrole; (3aR,6aR)-5-Methyl-1,3a,4,6a-tetrahydropyrrolo[3,4-b]pyrrole; Bicyclic pyrrolidine derivative; 5-Methyl-1,3a,4,6a-tetrahydropyrrolo[3,4-b]pyrrole (stereoisomer); Chiral pyrrolidine scaffold
EINECS	Contact for details

Quality Control

Our (3As,6As)-5-Methyloctahydropyrrolo[3,4-B]Pyrrole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We can support development with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.