Description

5-(2,2,2-Trifluoroethoxy)Pyrazine-2-Carboxylic Acid is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. Its unique structure, featuring a pyrazine core and a trifluoroethoxy side chain, makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorine moiety improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Investigated as a monomer or additive for developing advanced polymers and functional materials with specific electronic or surface properties.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated pyrazine derivatives.

Basic Information

Item	Details
Product Name	5-(2,2,2-Trifluoroethoxy)Pyrazine-2-Carboxylic Acid
CAS No.	1174323-36-4
Molecular Formula	C7H5F3N2O3
Molecular Weight	222.12 g/mol
Synonyms	2-Pyrazinecarboxylic acid, 5-(2,2,2-trifluoroethoxy)-; 5-(Trifluoroethoxy)pyrazine-2-carboxylic acid; 5-(2,2,2-Trifluoroethoxy)-2-pyrazinecarboxylic acid; 1174323-36-4; TFEPCA; Trifluoroethoxypyrazine carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 5-(2,2,2-Trifluoroethoxy)Pyrazine-2-Carboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and MS. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.