Description

Ethyl 3-Chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride is a high-purity, non-nucleoside building block of significant interest in modern pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of novel therapeutic agents, particularly those targeting central nervous system disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of innovative drug candidates. The compound's defined structure and purity are essential for ensuring reproducible results in complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological targets.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study biological pathways and protein functions.
• Process Chemistry Development: Serves as a starting material for scaling up and optimizing synthetic routes during pre-clinical and clinical development phases.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of investigational drugs.
• Academic Research: Utilized in university and institutional laboratories for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	Ethyl 3-Chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride
CAS No.	1174069-17-0
Molecular Formula	C10H13ClN3O2 • HCl
Molecular Weight	280.10 g/mol (Free base: 243.68 g/mol)
Synonyms	3-Chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylic acid ethyl ester hydrochloride; Ethyl 3-chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate HCl; Imidazo[1,2-a]pyrazine-2-carboxylic acid, 3-chloro-5,6,7,8-tetrahydro-, ethyl ester, hydrochloride; 1174069-17-0; Ethyl 3-chloro-5,6,7,8-tetrahydroimidazopyrazine-2-carboxylate hydrochloride; Benzodiazepine analogue intermediate
EINECS	Contact for details

Quality Control

Our Ethyl 3-Chloro-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine-2-carboxylate hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with the standards required for research and development under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.