Description

tert-Butyl 3-Formyl-5,6-Dihydro-[1,2,4]Triazolo[4,3-A]Pyrazine-7(8H)-Carboxylate is a high-value, multifunctional heterocyclic building block featuring both a formyl group and a Boc-protected amine, making it a versatile intermediate for advanced organic synthesis. This compound is critical for medicinal chemistry research and development, enabling the efficient construction of complex molecular architectures. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and other biologically relevant compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic programs.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization due to its reactive aldehyde and protected amine functionalities.
• Peptidomimetic Synthesis: Serves as a constrained dipeptide isostere or heterocyclic core in the design of peptidomimetics and macrocyclic compounds.
• Chemical Biology Probes: Employed in the development of chemical probes and tool compounds for target identification and validation in biological systems.
• Agrochemical Research: Potential intermediate in the discovery and development of new agrochemicals with specific biological activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	tert-Butyl 3-Formyl-5,6-Dihydro-[1,2,4]Triazolo[4,3-A]Pyrazine-7(8H)-Carboxylate
CAS No.	1174069-03-4
Molecular Formula	C11H16N4O3
Molecular Weight	252.27 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-3-formyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; tert-Butyl 3-formyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylate; 7-Boc-3-formyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; 3-Formyl-7-Boc-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine; BOC-3-CHO-THP; 1174069-03-4; 3-Formyl-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 3-Formyl-5,6-Dihydro-[1,2,4]Triazolo[4,3-A]Pyrazine-7(8H)-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All materials are characterized by modern analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is light-sensitive and easily oxidized; allow the sealed container to reach room temperature before opening to minimize moisture ingress and oxidative degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.