Description

(3S,4S)-1-Boc-4-Fluoro-3-Piperidinol CAS NO 1174020-45-1 is a high-purity, stereochemically defined fluorinated piperidine derivative, serving as a critical chiral building block in modern organic synthesis. Its value lies in the precise introduction of both fluorine and a protected amine functionality, enabling the development of compounds with enhanced metabolic stability and targeted biological activity. This advanced pharmaceutical intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and oncology drug candidates.
• Protease Inhibitor Development: Used in constructing the core scaffolds of fluorinated protease inhibitors, leveraging the fluorine atom for binding affinity and selectivity.
• Agrochemical Synthesis: Serves as a precursor for novel fluorinated pesticides and herbicides, where the fluorine atom can improve lipophilicity and environmental stability.
• PET (Positron Emission Tomography) Tracer Precursor: Potential use as a building block for fluorine-18 labeled radiopharmaceuticals for diagnostic imaging.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship exploration by providing a defined stereochemical and fluorinated point of diversity.
• Peptidomimetic Chemistry: Incorporated into peptide backbones to create metabolically stable analogues for therapeutic applications.

Basic Information

Product Name	(3S,4S)-1-Boc-4-Fluoro-3-Piperidinol
CAS No.	1174020-45-1
Molecular Formula	C10H18FNO3
Molecular Weight	219.26 g/mol
Synonyms	(3S,4S)-4-Fluoro-3-hydroxy-1-(tert-butoxycarbonyl)piperidine; (3S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-3-piperidinol; (3S,4S)-N-Boc-4-fluoro-3-piperidinol; 1-Boc-(3S,4S)-4-fluoro-3-piperidinol; tert-Butyl (3S,4S)-4-fluoro-3-hydroxypiperidine-1-carboxylate; (3S,4S)-4-Fluoro-3-piperidinol, 1-Boc protected; Boc-(3S,4S)-4-Fluoro-3-piperidinol
EINECS	Contact for details

Quality Control

Our (3S,4S)-1-Boc-4-Fluoro-3-Piperidinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure stereochemical purity and identity confirmation by NMR and mass spectrometry. We provide Certificates of Analysis (COA) with detailed specifications for every shipment, ensuring traceability and compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.