Description

tert-Butyl (3S,4R)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate is a high-value, stereochemically defined piperidine derivative, serving as a critical chiral building block in modern synthetic chemistry. Its core value lies in providing a rigid, functionalized scaffold with defined stereochemistry, which is essential for constructing complex molecules with high biological specificity. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially those targeting neurological receptors and viral proteases.
• Advanced Organic Synthesis: Used as a versatile building block for constructing complex natural products and other bioactive molecules requiring a fluorinated, hydroxylated piperidine core.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the impact of fluorine substitution and stereochemistry on drug potency and metabolic stability.
• Process Chemistry & Scale-Up: Serves as a starting material or intermediate in the development and optimization of scalable, cost-effective synthetic routes for target molecules.
• Agrochemical Research: Potential application in the synthesis of novel, high-performance crop protection agents with enhanced activity.

Basic Information

Product Name	tert-Butyl (3S,4R)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate
CAS No.	1174020-40-6
Molecular Formula	C10H18FNO3
Molecular Weight	219.26 g/mol
Synonyms	1-Boc-3-fluoro-4-hydroxypiperidine (stereospecific); (3S,4R)-1-(tert-Butoxycarbonyl)-3-fluoro-4-hydroxypiperidine; tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate (cis); 1-N-Boc-3-fluoro-4-hydroxypiperidine; (3S,4R)-3-Fluoro-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; BOC-3-Fluoro-4-hydroxypiperidine; 1174020-40-6
EINECS	Contact for details

Quality Control

Our tert-Butyl (3S,4R)-3-Fluoro-4-Hydroxypiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, confirming compliance with customer requirements and internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.