Description

1-(5-Chloro-2-Fluorobenzoyl)Piperazine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a CAS number of 1172407-04-3. This compound is a critical building block in the synthesis of active pharmaceutical ingredients (APIs), valued for its precise chemical structure that enables targeted molecular modifications. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery.
• Biochemical Reagent: Employed in biochemical assays and as a reference standard in analytical laboratories.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Product Name	1-(5-Chloro-2-Fluorobenzoyl)Piperazine Hydrochloride
CAS No.	1172407-04-3
Molecular Formula	C11H13ClF N2O • HCl
Molecular Weight	277.10 g/mol (Free base: 240.69 g/mol)
Synonyms	1-[(5-Chloro-2-fluorophenyl)carbonyl]piperazine hydrochloride; 5-Chloro-2-fluoro-N-piperazin-1-ylbenzamide hydrochloride; Piperazine, 1-(5-chloro-2-fluorobenzoyl)-, hydrochloride; 1172407-04-3; 5-Chloro-2-fluorobenzoylpiperazine HCl; 1-(5-Chloro-2-fluorobenzoyl)piperazine HCl salt
EINECS	Contact for details

Quality Control

Our 1-(5-Chloro-2-Fluorobenzoyl)Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.