Description

4-(5-Fluoro-2-Methyl-Benzyl)-Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific piperidine-based structure. This compound is critical for research and development in medicinal chemistry, serving as a key building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for CNS-targeting therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its fluorinated benzyl-piperidine scaffold.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block in the multi-step synthesis of potential APIs for clinical trials.
• Biochemical Tool Compound: May be employed in pharmacological assays and as a reference standard in analytical method development.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.

Basic Information

Product Name	4-(5-Fluoro-2-Methyl-Benzyl)-Piperidine Hydrochloride
CAS No.	1172405-87-6
Molecular Formula	C14H20FClN
Molecular Weight	257.77 g/mol
Synonyms	4-[(5-Fluoro-2-methylphenyl)methyl]piperidine hydrochloride; 1-(5-Fluoro-2-methylbenzyl)piperidin-4-amine hydrochloride (tautomer); 4-(5-Fluoro-2-methylbenzyl)piperidine HCl; 1172405-87-6; 4-(5-Fluoro-o-tolylmethyl)piperidine hydrochloride; Piperidine, 4-[(5-fluoro-2-methylphenyl)methyl]-, hydrochloride (1:1); 4-(5-Fluoro-2-methyl-benzyl)-piperidine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(5-Fluoro-2-Methyl-Benzyl)-Piperidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under ICH guidelines and can supply material suitable for use in cGMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.