Description

3-Bromo-5,6,7,8-Tetrahydro[1,2,4]Triazolo[4,3-A]Pyrazine Hcl is a high-purity, heterocyclic organic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in medicinal chemistry and process development. The compound's unique fused triazolo-pyrazine structure offers a versatile scaffold for creating targeted molecular libraries.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Library Synthesis: Valuable scaffold for generating diverse compound libraries in high-throughput screening (HTS) programs.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for potential APIs.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biological target identification and validation studies.

Basic Information

Product Name	3-Bromo-5,6,7,8-Tetrahydro[1,2,4]Triazolo[4,3-A]Pyrazine Hcl
CAS No.	1172057-73-6
Molecular Formula	C6H9BrClN5
Molecular Weight	266.53 g/mol
Synonyms	3-Bromo-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride; 3-Bromo-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazine HCl; 1172057-73-6; 3-Bromo-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine hydrochloride; 3-Bromotetrahydrotriazolopyrazine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-5,6,7,8-Tetrahydro[1,2,4]Triazolo[4,3-A]Pyrazine Hcl is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) compliance for advanced intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.