Description

3-(5-Fluoro-2-Methoxy-Benzyl)-Piperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1171433-31-0. This compound is a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is essential for research and development chemists, process scale-up engineers, and manufacturers in the global pharmaceutical and biotechnology industries seeking reliable, high-quality raw materials for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development and commercial production of new drug candidates, especially for neurological and psychiatric applications.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in multi-step synthesis to construct the core piperidine-benzyl pharmacophore found in various therapeutic agents.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic pathways from laboratory scale to pilot plant and full commercial manufacturing.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for the production of client-specific drug substances.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and regulatory submission support.

Basic Information

Product Name	3-(5-Fluoro-2-Methoxy-Benzyl)-Piperidine Hydrochloride
CAS No.	1171433-31-0
Molecular Formula	C14H20FNO2 • HCl
Molecular Weight	289.78 g/mol (Free base: 253.31 g/mol)
Synonyms	3-[(5-Fluoro-2-methoxyphenyl)methyl]piperidine hydrochloride; 1-(5-Fluoro-2-methoxybenzyl)piperidin-3-amine hydrochloride; 5-Fluoro-2-methoxybenzylpiperidine-3-amine HCl; 3-(5-Fluoro-2-methoxybenzyl)piperidine HCl; 1171433-31-0; 3-(5-Fluoro-2-methoxy-benzyl)-piperidine HCl salt
EINECS	Contact for details

Quality Control

Our 3-(5-Fluoro-2-Methoxy-Benzyl)-Piperidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.