Description

1-[4-(Trifluoromethyl)Benzoyl]Piperazine Hydrochloride is a high-purity, synthetically versatile trifluoromethylated benzoyl piperazine derivative. This compound serves as a critical pharmaceutical intermediate and research chemical for the development of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to the presence of the trifluoromethyl and piperazine pharmacophores.
• Chemical Synthesis: Serves as a versatile precursor for the preparation of amides, esters, and other derivatives for library synthesis.
• Biochemical Research: Potential use as a tool compound or ligand in biochemical assays and target validation studies.
• Agrochemical Development: Intermediate in the research and synthesis of novel crop protection agents and pesticides.
• Material Science: Potential monomer or additive in the development of specialty polymers and advanced materials.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Benzoyl]Piperazine Hydrochloride
CAS No.	1171417-73-4
Molecular Formula	C12H14ClF3N2O
Molecular Weight	294.70 g/mol
Synonyms	4-(Trifluoromethyl)benzoylpiperazine hydrochloride; 1-[(4-Trifluoromethyl)benzoyl]piperazine HCl; Piperazine, 1-[(4-trifluoromethyl)benzoyl]-, hydrochloride; 1-(4-Trifluoromethylbenzoyl)piperazine hydrochloride; 1-(4-(Trifluoromethyl)benzoyl)piperazine HCl; 4-(Trifluoromethyl)-N-piperazin-1-ylbenzamide hydrochloride; 4-(Trifluoromethyl)benzoic acid piperazide hydrochloride
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)Benzoyl]Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.