Description

(6S,8R)-8-Hydroxy-1,4-Diazabicyclo-[4.3.0]Nonane is a high-purity, chiral bicyclic diamine derivative that serves as a critical advanced pharmaceutical intermediate (API) and a versatile chiral building block in organic synthesis. Its value lies in its unique stereochemistry and functional groups, enabling the precise construction of complex molecules with defined three-dimensional structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require high-quality, stereochemically defined intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral drugs.
• Asymmetric Catalysis: Used as a precursor or ligand for chiral catalysts in enantioselective synthesis, crucial for producing single-isomer compounds.
• Agrochemical Synthesis: Employed in the research and production of advanced, stereospecific pesticides and herbicides.
• Fine Chemical Production: Serves as a specialized intermediate for creating complex fragrance molecules, dyes, and other high-value specialty chemicals.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs and process chemistry research in academic and industrial R&D laboratories.
• Peptidomimetics: The diazabicyclo core structure makes it a useful scaffold for designing and synthesizing peptide mimics with enhanced stability and bioavailability.

Basic Information

Product Name	(6S,8R)-8-Hydroxy-1,4-Diazabicyclo-[4.3.0]Nonane
CAS No.	1161000-19-6
Molecular Formula	C7H14N2O
Molecular Weight	142.20 g/mol
Synonyms	(6S,8R)-8-Hydroxy-1,4-diazabicyclo[4.3.0]nonane; 8-Hydroxy-1,4-diazabicyclo[4.3.0]nonane, (6S,8R)-; (6S,8R)-8-Hydroxyhexahydro-1H-pyrrolo[1,2-a]pyrazine; (6S,8R)-8-Hydroxyoctahydro-1H-pyrrolo[1,2-a]pyrazine; (6S,8R)-8-Hydroxy-1,4-diazabicyclononane; 1,4-Diazabicyclo[4.3.0]nonan-8-ol, (6S,8R)-; Chiral Hydroxy Diazabicyclononane; 8-Hydroxy-DBN derivative
EINECS	Contact for details

Quality Control

Our (6S,8R)-8-Hydroxy-1,4-Diazabicyclo-[4.3.0]Nonane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.