Description

2-{[4-(tert-Butoxycarbonyl)Piperazino]-Carbonyl}Cyclopropanecarboxylic Acid is a sophisticated bifunctional organic building block that integrates a cyclopropane carboxylic acid moiety with a Boc-protected piperazine unit. This compound is of significant value in pharmaceutical research and development, primarily serving as a key intermediate for the synthesis of complex molecules. It is specifically designed for medicinal chemists and process development scientists working in the fields of drug discovery and fine chemical manufacturing. The structural features of this molecule enable its use in constructing novel active pharmaceutical ingredients (APIs) and advanced chemical entities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Protease Inhibitor Synthesis: Used in the research and development of protease inhibitors, where the cyclopropane and piperazine motifs are common pharmacophores.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing and synthesizing peptidomimetics to improve metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the creation of specialized probes and tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing high-value intermediates under cGMP conditions.
• Library Synthesis for High-Throughput Screening: Facilitates the rapid generation of diverse compound libraries for screening against novel biological targets.

Basic Information

Product Name	2-{[4-(tert-Butoxycarbonyl)Piperazino]-Carbonyl}Cyclopropanecarboxylic Acid
CAS No.	1160474-45-2
Molecular Formula	C14H22N2O5
Molecular Weight	298.34 g/mol
Synonyms	2-((4-(tert-Butoxycarbonyl)piperazine-1-carbonyl)cyclopropane-1-carboxylic acid; 1-Boc-piperazine-4-carboxylic acid cyclopropane-1,2-dicarboxylic acid monoamide; 2-[(4-{[(1,1-Dimethylethoxy)carbonyl]amino}piperidin-1-yl)carbonyl]cyclopropanecarboxylic acid (related isomer); BOC-Pip-Cyclopropane-COOH; tert-Butyl 4-[(1-carboxycyclopropan-2-yl)carbonyl]piperazine-1-carboxylate; Cyclopropane-1-carboxylic acid, 2-[(4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl)carbonyl]-; 1160474-45-2.
EINECS	Contact for details

Quality Control

Our production of 2-{[4-(tert-Butoxycarbonyl)Piperazino]-Carbonyl}Cyclopropanecarboxylic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We employ advanced analytical techniques including HPLC, NMR, and MS for characterization. While typically supplied as a standard R&D grade, production under cGMP guidelines can be discussed for advanced project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.