Description

7-Chloro-2-(3-Ethoxyphenyl)-8-Methylquinoline-4-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive carbonyl chloride functional group. This compound is critical for the synthesis of complex molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates, particularly in oncology and anti-infective therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules for clinical development.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemicals, and other high-value organic compounds requiring the quinoline scaffold.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory chemical synthesis and methodological development.

Basic Information

Product Name	7-Chloro-2-(3-Ethoxyphenyl)-8-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160263-74-0
Molecular Formula	C20H15Cl2NO2
Molecular Weight	372.25 g/mol
Synonyms	4-Chlorocarbonyl-7-chloro-2-(3-ethoxyphenyl)-8-methylquinoline; 7-Chloro-2-(3-ethoxyphenyl)-8-methyl-4-quinolinecarbonyl chloride; 7-Chloro-2-(3-ethoxyphenyl)-8-methylquinoline-4-carboxylic acid chloride; 8-Methyl-7-chloro-2-(3-ethoxyphenyl)quinoline-4-carbonyl chloride; 2-(3-Ethoxyphenyl)-7-chloro-8-methylquinoline-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 7-Chloro-2-(3-Ethoxyphenyl)-8-Methylquinoline-4-Carbonyl Chloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.