Description

2-(2,5-Dimethylphenyl)-8-Ethylquinoline-4-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive acid chloride functional group. This compound is critical for the synthesis of complex organic molecules, particularly in medicinal chemistry where it serves as a key building block for active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug candidates, particularly in oncology and antiviral research.
• Organic Synthesis Reagent: Used in amide coupling reactions to introduce the quinoline-carboxamide moiety into larger molecular frameworks.
• Research & Development (R&D): Essential for medicinal chemists in academic, government, and industrial labs for structure-activity relationship (SAR) studies and lead optimization.
• API Manufacturing: Serves as a precursor in the scaled-up production of Active Pharmaceutical Ingredients (APIs) requiring this specific heterocyclic structure.
• Chemical Biology Probes: Can be utilized to create labeled compounds or probes for studying biological pathways and target engagement.
• Material Science Research: Potential use in the development of organic electronic materials or metal-organic frameworks (MOFs) due to its conjugated quinoline system.

Basic Information

Product Name	2-(2,5-Dimethylphenyl)-8-Ethylquinoline-4-Carbonyl Chloride
CAS No.	1160261-17-5
Molecular Formula	C20H18ClNO
Molecular Weight	323.82 g/mol
Synonyms	8-Ethyl-2-(2,5-dimethylphenyl)quinoline-4-carbonyl chloride; 2-(2,5-Dimethylphenyl)-8-ethyl-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 2-(2,5-dimethylphenyl)-8-ethyl-; 1160261-17-5; 8-Ethyl-2-(2,5-xylyl)quinoline-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2-(2,5-Dimethylphenyl)-8-Ethylquinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.