Description

3-Ethoxy-4-[(2-Fluorobenzyl)Oxy]Benzoyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive benzoyl chloride functional group and specific ether-fluorobenzyl substitution pattern. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in research and development targeting novel therapeutic agents. It is primarily utilized by pharmaceutical manufacturers and R&D organizations specializing in medicinal chemistry and process development for new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those requiring a specific fluorinated benzyloxy-ethoxy benzoyl moiety.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with potential biological activity.
• Process Chemistry Development: Serves as a critical reagent in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of specialized, high-value compounds for the life sciences industry.
• Agrochemical Intermediate: Potential use in the research and development of advanced agrochemicals requiring fluorinated aromatic structures.
• Material Science Precursor: Can be utilized in the synthesis of specialty polymers or liquid crystals where the specific molecular architecture is required.

Basic Information

Product Name	3-Ethoxy-4-[(2-Fluorobenzyl)Oxy]Benzoyl Chloride
CAS No.	1160260-00-3
Molecular Formula	C16H14ClFO3
Molecular Weight	308.73 g/mol
Synonyms	4-(2-Fluorobenzyloxy)-3-ethoxybenzoyl chloride; 3-Ethoxy-4-(2-fluorobenzyloxy)benzoyl chloride; 2-Fluoro-α-[(4-(chlorocarbonyl)-2-ethoxyphenoxy)methyl]benzene; Benzoyl chloride, 3-ethoxy-4-[(2-fluorophenyl)methoxy]-; 1160260-00-3
EINECS	Contact for details

Quality Control

Our production of 3-Ethoxy-4-[(2-Fluorobenzyl)Oxy]Benzoyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC, GC, and NMR, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development under quality agreements and can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its acid chloride nature and sensitivity to moisture, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.