Description

7-Chloro-2-(4-Ethylphenyl)-8-Methylquinoline-4-Carbonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive carbonyl chloride functional group. This compound is of significant commercial importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-quality intermediates for scale-up and manufacturing.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel quinoline-based drug candidates, particularly in oncology and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the quinoline scaffold for biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and cellular processes.
• Custom Synthesis & Contract Manufacturing: A vital component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	7-Chloro-2-(4-Ethylphenyl)-8-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160256-04-1
Molecular Formula	C20H15Cl2NO
Molecular Weight	356.25 g/mol
Synonyms	4-Quinolinecarbonyl chloride, 7-chloro-2-(4-ethylphenyl)-8-methyl-; 7-Chloro-2-(p-ethylphenyl)-8-methylquinoline-4-carbonyl chloride; 2-(4-Ethylphenyl)-7-chloro-8-methyl-4-quinolinecarbonyl chloride; 1160256-04-1; 7-Chloro-2-(4-ethylphenyl)-8-methyl-4-quinolinecarbonyl chloride; 7-Chloro-2-(4-ethylphenyl)-8-methylquinoline-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 7-Chloro-2-(4-Ethylphenyl)-8-Methylquinoline-4-Carbonyl Chloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.