Description

2-(4-Chlorophenyl)-8-Methylquinoline-4-Carbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. This compound matters as a critical building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to introduce the quinoline pharmacophore into novel compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting infectious diseases or cancer, where the quinoline core is a privileged scaffold.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its bioactive quinoline structure.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic semiconductors, light-emitting diodes (OLEDs), and other functional materials requiring complex heterocyclic components.
• Custom Synthesis and Contract Manufacturing: A vital reagent for fine chemical manufacturers offering bespoke synthesis services to clients in life sciences.
• Academic and Industrial R&D: Fundamental building block in medicinal chemistry labs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	2-(4-Chlorophenyl)-8-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160254-33-0
Molecular Formula	C18H11Cl2NO
Molecular Weight	328.19 g/mol
Synonyms	8-Methyl-2-(4-chlorophenyl)quinoline-4-carbonyl chloride; 2-(p-Chlorophenyl)-8-methyl-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 2-(4-chlorophenyl)-8-methyl-; 1160254-33-0; 2-(4-Chlorophenyl)-8-methylquinoline-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 2-(4-Chlorophenyl)-8-Methylquinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in cGMP and ISO 9001 environments for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.