Description

1-n-Boc-4-(4-Bromo-2-Chlorophenoxy)Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine core with a halogenated phenoxy substituent. This compound is critical for medicinal chemists in the research and development of novel small-molecule therapeutics, particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring a reliable, high-quality building block for complex synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel therapeutic agents.
• Kinase Inhibitor Development: Serves as a core scaffold or precursor in the synthesis of targeted kinase inhibitors for oncology and inflammatory diseases.
• CNS Drug Discovery: Employed in the synthesis of compounds targeting neurological and psychiatric disorders.
• Custom Synthesis & Scale-Up: A starting material for contract manufacturing organizations (CMOs) performing custom synthesis from gram to kilogram scale.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation.

Basic Information

Product Name	1-n-Boc-4-(4-Bromo-2-Chlorophenoxy)Piperidine
CAS No.	1159825-39-4
Molecular Formula	C16H21BrClNO3
Molecular Weight	390.70 g/mol
Synonyms	1-Boc-4-(4-Bromo-2-chlorophenoxy)piperidine; tert-Butyl 4-(4-bromo-2-chlorophenoxy)piperidine-1-carboxylate; 4-(4-Bromo-2-chlorophenoxy)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-bromo-2-chlorophenoxy)piperidine; N-Boc-4-(4-Bromo-2-chlorophenoxy)piperidine; Piperidine, 4-[(4-bromo-2-chlorophenyl)oxy]-, 1-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(4-Bromo-2-Chlorophenoxy)Piperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use and can supply material produced under cGMP guidelines for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.