Description

4-n-Cbz-2-Hydroxymethylpiperazine -Hcl CAS NO 1159825-20-3 is a high-purity, protected piperazine derivative primarily used as a critical building block in pharmaceutical research and development. This compound is essential for medicinal chemists designing and synthesizing novel drug candidates, particularly in the areas of protease inhibitors and other small molecule therapeutics. Its key value lies in providing a versatile, functionalized scaffold that enables the controlled introduction of the piperazine moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Protease Inhibitor Development: Used in the research and production of protease inhibitors, including those targeting viral proteases.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile building block for constructing compound libraries and optimizing lead molecules in preclinical studies.
• Peptidomimetics: Employed in the design and synthesis of peptide-like molecules with enhanced stability and bioavailability.
• Chemical Biology Research: Utilized as a tool compound or a precursor for probes studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4-n-Cbz-2-Hydroxymethylpiperazine -Hcl
CAS No.	1159825-20-3
Molecular Formula	C14H21N3O3 • HCl
Molecular Weight	315.79 g/mol (Free base: 279.33 g/mol)
Synonyms	1-Carbobenzoxy-2-hydroxymethylpiperazine hydrochloride; N-Cbz-2-(Hydroxymethyl)piperazine hydrochloride; (2-Hydroxymethyl-piperazin-1-yl)-carbamic acid benzyl ester hydrochloride; 1-[(Benzyloxy)carbonyl]-2-(hydroxymethyl)piperazine hydrochloride; 4-Cbz-2-Hydroxymethylpiperazine HCl; Piperazine, 1-[(phenylmethoxy)carbonyl]-2-(hydroxymethyl)-, hydrochloride (1:1); CBZ-2-HMP • HCl
EINECS	Contact for details

Quality Control

Our 4-n-Cbz-2-Hydroxymethylpiperazine -Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.