Description

1-n-Boc-4-(4-Carbamoylpyridin-2-Yl)Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core protected by a tert-butoxycarbonyl (Boc) group and functionalized with a carbamoylpyridine moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions engaged in the discovery of new chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex small-molecule active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The pyridine-carboxamide structure makes it a valuable fragment for designing and synthesizing potential kinase inhibitors for cancer therapy.
• CNS Drug Discovery: Employed in the research of novel compounds targeting neurological disorders due to the piperazine moiety's prevalence in CNS-active molecules.
• Custom Synthesis Building Block: Supplied to CROs and CMOs for custom synthesis projects requiring specific, high-purity heterocyclic intermediates.
• Process Chemistry: Used in route scouting and scale-up studies for the development of efficient and cost-effective commercial manufacturing processes for new drugs.

Basic Information

Product Name	1-n-Boc-4-(4-Carbamoylpyridin-2-Yl)Piperazine
CAS No.	1159823-86-5
Molecular Formula	C15H22N4O3
Molecular Weight	306.36 g/mol
Synonyms	1-Boc-4-(2-Pyridinecarboxamido-4-yl)piperazine; tert-Butyl 4-(4-carbamoylpyridin-2-yl)piperazine-1-carboxylate; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)isonicotinamide; 1-(tert-Butoxycarbonyl)-4-(4-carbamoyl-2-pyridyl)piperazine; 2-(1-Boc-4-piperazinyl)isonicotinamide; BOC-Piperazine-Pyridine-Carboxamide Intermediate; 1159823-86-5
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(4-Carbamoylpyridin-2-Yl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.