Description

(R)-1,4-(Di-Boc)-2-(Hydroxymethyl)Piperazine is a high-purity, chiral piperazine derivative, serving as a critical protected intermediate in advanced organic synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require building blocks for active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis and metal complexation.
• Peptidomimetics: Incorporation into peptide backbones to create stable, bioactive peptidomimetic structures with defined stereochemistry.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study biological pathways and protein interactions.
• Agrochemical Research: Intermediate in the development of new chiral active ingredients for crop protection agents.
• Academic & Contract Research: Valuable reagent for universities and CROs (Contract Research Organizations) engaged in synthetic methodology and medicinal chemistry projects.

Basic Information

Product Name	(R)-1,4-(Di-Boc)-2-(Hydroxymethyl)Piperazine
CAS No.	1159598-21-6
Molecular Formula	C16H30N2O5
Molecular Weight	330.42 g/mol
Synonyms	(R)-2-(Hydroxymethyl)-1,4-bis(tert-butoxycarbonyl)piperazine; (R)-1,4-Di-Boc-2-piperazinemethanol; (R)-1,4-Bis(tert-butoxycarbonyl)-2-(hydroxymethyl)piperazine; (R)-N,N'-Di-Boc-2-(hydroxymethyl)piperazine; (R)-2-Hydroxymethyl-1,4-di-Boc-piperazine; (2R)-1,4-Bis[(2-methylpropan-2-yl)oxycarbonyl]-2-(hydroxymethyl)piperazine; (R)-1,4-Di-Boc-2-hydroxymethylpiperazine
EINECS	Contact for details

Quality Control

Our (R)-1,4-(Di-Boc)-2-(Hydroxymethyl)Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support compliance with cGMP and ISO standards for advanced intermediates, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.