Description

5-tert-Butyl-2-Piperazin-1-Yl-1,3-Benzoxazole Hydrochloride is a high-purity, advanced pharmaceutical intermediate with significant relevance in modern drug discovery and development. This compound is valued for its role as a key building block in the synthesis of novel therapeutic agents, particularly those targeting central nervous system and oncological pathways. It is primarily sought after by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new bioactive molecules.
• API Development: Serves as a key fragment in the construction of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis: Employed by fine chemical manufacturers for the contract synthesis of specialized, high-value compounds for client projects.

Basic Information

Product Name	5-tert-Butyl-2-Piperazin-1-Yl-1,3-Benzoxazole Hydrochloride
CAS No.	1158487-44-5
Molecular Formula	C17H24N4O·HCl
Molecular Weight	336.86 g/mol (Free base: 300.40 g/mol)
Synonyms	5-tert-Butyl-2-(piperazin-1-yl)-1,3-benzoxazole hydrochloride; 2-(1-Piperazinyl)-5-(1,1-dimethylethyl)benzoxazole hydrochloride; 5-tert-Butyl-2-piperazinylbenzoxazole HCl; 1158487-44-5; Benzoxazole, 5-(1,1-dimethylethyl)-2-(1-piperazinyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our 5-tert-Butyl-2-Piperazin-1-Yl-1,3-Benzoxazole Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.