Description

4-Carboxymethyl-Piperazine-1-Carboxylic Acid Benzyl Ester is a versatile and high-purity chemical building block essential for advanced organic synthesis. Its molecular structure, featuring both a protected carboxylic acid and a piperazine ring, makes it a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce the piperazine-carboxylate moiety into peptide backbones to modify stability, bioavailability, and receptor binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal complexation.
• Custom Synthesis and Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client R&D pipelines.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and medicinal chemistry.
• Chemical Library Production: A valuable building block for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Item	Detail
Product Name	4-Carboxymethyl-Piperazine-1-Carboxylic Acid Benzyl Ester
CAS No.	1153907-60-8
Molecular Formula	C15H20N2O4
Molecular Weight	292.33 g/mol
Synonyms	1-Carboxy-4-(benzyloxycarbonyl)piperazine; Benzyl 4-(carboxymethyl)piperazine-1-carboxylate; 1-(Benzyloxycarbonyl)-4-(carboxymethyl)piperazine; 4-(Benzyloxycarbonyl)piperazine-1-acetic acid; 1-Carboxy-4-[(phenylmethoxy)carbonyl]piperazine; Piperazine-1-acetic acid, 4-(benzyloxycarbonyl)-; Z-Pip-OH
EINECS	Contact for details

Quality Control

Every batch of 4-Carboxymethyl-Piperazine-1-Carboxylic Acid Benzyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure the material meets the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments, supporting regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.