Description

(2R,5R)-1,2,5-Trimethylpiperazine is a high-purity, stereochemically defined chiral piperazine derivative of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block and intermediate for the development of active pharmaceutical ingredients (APIs), particularly in creating molecules with specific three-dimensional configurations. It is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries where precise stereochemistry is required for biological activity and process optimization.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug molecules, including potential antiviral, anticancer, and central nervous system (CNS) agents.
• Ligand and Catalyst Precursor: Used in the preparation of chiral ligands for asymmetric catalysis, enabling enantioselective transformations in fine chemical manufacturing.
• Agrochemical Research: Serves as a building block for developing novel, stereospecific pesticides and herbicides with enhanced efficacy and selectivity.
• Chemical Reference Standard: Employed as a high-purity standard in analytical method development and quality control for chiral separation techniques like HPLC and SFC.
• Academic & R&D: Utilized in medicinal chemistry and organic synthesis research for exploring new synthetic pathways and structure-activity relationships (SAR).

Basic Information

Product Name	(2R,5R)-1,2,5-Trimethylpiperazine
CAS No.	1152368-00-7
Molecular Formula	C7H16N2
Molecular Weight	128.22 g/mol
Synonyms	(2R,5R)-1,2,5-Trimethylpiperazine; (2R,5R)-1,2,5-TMP; (2R,5R)-TMP; (R,R)-1,2,5-Trimethylpiperazine; 1,2,5-Trimethylpiperazine, (2R,5R)-; Piperazine, 1,2,5-trimethyl-, (2R,5R)-; (2R,5R)-1,2,5-TriMePip
EINECS	Contact for details

Quality Control

Our (2R,5R)-1,2,5-Trimethylpiperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.