Description

(3S,5R)-tert-Butyl 3,5-Dimethylpiperazine-1-Carboxylate is a high-purity, stereochemically defined piperazine derivative serving as a critical chiral building block in advanced organic synthesis. Its primary value lies in providing a rigid, protected diamine scaffold essential for constructing complex molecules with precise three-dimensional architecture. This compound is particularly vital for pharmaceutical R&D and process chemistry teams developing new active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring sophisticated chiral amines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Asymmetric Catalyst Ligand Precursor: Used to develop chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Peptidomimetic Chemistry: Incorporates the constrained piperazine ring into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for creating advanced, stereospecific crop protection agents.
• Chemical Biology Probe Development: Utilized in constructing molecular probes to study enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	(3S,5R)-tert-Butyl 3,5-Dimethylpiperazine-1-Carboxylate
CAS No.	1152111-14-2
Molecular Formula	C11H22N2O2
Molecular Weight	214.31 g/mol
Synonyms	1-Boc-(3S,5R)-3,5-dimethylpiperazine; tert-Butyl (3S,5R)-3,5-dimethylpiperazine-1-carboxylate; (3S,5R)-1-N-Boc-3,5-dimethylpiperazine; 1-(tert-Butoxycarbonyl)-(3S,5R)-3,5-dimethylpiperazine; (3S,5R)-3,5-Dimethyl-1-(tert-butoxycarbonyl)piperazine; Boc-(3S,5R)-3,5-Dimethylpiperazine; (3S,5R)-1-Boc-3,5-dimethylpiperazine
EINECS	Contact for details

Quality Control

Every batch of (3S,5R)-tert-Butyl 3,5-Dimethylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation upon prolonged exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.