Description

Piperazine, 1,3-Dimethyl-, Hydrochloride (1:2), (3R)- is a high-purity, chiral piperazine derivative supplied as a dihydrochloride salt. This compound is a critical building block in the synthesis of advanced pharmaceutical intermediates and active pharmaceutical ingredients (APIs), particularly for chiral drug development. It is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel therapeutic agents, including central nervous system (CNS) drugs and receptor modulators.
• API Synthesis: Used in the multi-step synthesis of complex, stereochemically defined Active Pharmaceutical Ingredients (APIs).
• Agrochemical Research: Serves as a precursor in the creation of new chiral pesticides and herbicides with enhanced efficacy and selectivity.
• Catalyst Ligand Preparation: Can be utilized to develop chiral ligands for asymmetric catalysis in fine chemical manufacturing.
• Academic & R&D: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and novel compound library generation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing bespoke compounds for client projects.

Basic Information

Product Name	Piperazine, 1,3-Dimethyl-, Hydrochloride (1:2), (3R)-
CAS No.	1152110-26-3
Molecular Formula	C6H14N2 · 2HCl
Molecular Weight	215.11 g/mol
Synonyms	(3R)-1,3-Dimethylpiperazine Dihydrochloride; (R)-1,3-Dimethylpiperazine Dihydrochloride; (R)-1,3-Dimethylpiperazine · 2HCl; (R)-N,N'-Dimethylpiperazine Dihydrochloride; (R)-(-)-1,3-Dimethylpiperazine Dihydrochloride; 1,3-Dimethyl-(3R)-piperazine Dihydrochloride; (3R)-(-)-1,3-Dimethylpiperazine Dihydrochloride
EINECS	Contact for details

Quality Control

Our Piperazine, 1,3-Dimethyl-, Hydrochloride (1:2), (3R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.