Description

2-[(2R,6S)-2,6-Dimethylpiperazin-1-Yl]Acetamide Dihydrochloride is a high-purity chiral piperazine derivative, serving as a critical building block in advanced pharmaceutical synthesis. This compound is valued for its role in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of complex drug molecules, including potential kinase inhibitors and central nervous system (CNS) agents.
• Drug Discovery & Medicinal Chemistry: Used as a versatile scaffold for constructing compound libraries and optimizing lead structures in early-stage R&D.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the scalable production of target APIs under Good Manufacturing Practice (GMP) guidelines.
• Biochemical Research: Acts as a precursor or reference standard in biochemical assays and pharmacological studies investigating specific receptor interactions.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	2-[(2R,6S)-2,6-Dimethylpiperazin-1-Yl]Acetamide Dihydrochloride
CAS No.	1148003-52-4
Molecular Formula	C9H20Cl2N4O
Molecular Weight	271.19 g/mol
Synonyms	(2R,6S)-1-(2-Amino-2-oxoethyl)-2,6-dimethylpiperazine dihydrochloride; 2-((2R,6S)-2,6-Dimethylpiperazin-1-yl)acetamide dihydrochloride; (2R,6S)-N-(2,6-Dimethylpiperazin-1-yl)acetamide dihydrochloride; Acetamide, 2-[(2R,6S)-2,6-dimethyl-1-piperazinyl]-, dihydrochloride; 1148003-52-4; (2R,6S)-DMAPAA dihydrochloride
EINECS	Contact for details

Quality Control

Our 2-[(2R,6S)-2,6-Dimethylpiperazin-1-Yl]Acetamide Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with data from HPLC, NMR, and chiral purity analysis. Specifications are designed to meet the stringent requirements of pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.