Description

tert-Butyl 4-(6-Chloropyrazin-2-Ylamino)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily utilized by research institutions, contract research and manufacturing organizations (CROs/CMOs), and pharmaceutical companies engaged in the development of small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop novel pharmacologically active molecules.
• API Synthesis: Employed in the multi-step synthesis of final Active Pharmaceutical Ingredients (APIs) that incorporate the piperidine-pyrazine pharmacophore.
• Custom Synthesis & Scale-Up: Serves as a starting material for contract manufacturing organizations (CMOs) providing custom synthesis services from milligram to kilogram scale.
• Bioconjugation & Probe Development: Potential use in the development of chemical probes and bioconjugates for biochemical and diagnostic research due to its reactive amine group.

Basic Information

Product Name	tert-Butyl 4-(6-Chloropyrazin-2-Ylamino)Piperidine-1-Carboxylate
CAS No.	1147998-25-1
Molecular Formula	C14H20ClN5O2
Molecular Weight	325.79 g/mol
Synonyms	1-Boc-4-[(6-chloropyrazin-2-yl)amino]piperidine; 4-[(6-Chloro-2-pyrazinyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-[(6-chloropyrazin-2-yl)amino]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(6-chloropyrazin-2-yl)amino]piperidine; BOC-4-(6-Chloropyrazin-2-ylamino)piperidine; N-Boc-4-(6-chloropyrazin-2-ylamino)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(6-Chloropyrazin-2-Ylamino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for pharmaceutical intermediates in development and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.