Description

1-(Tetrahydro-2H-Pyran-4-Yl)-2-Piperazinone is a high-purity heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical scaffold for medicinal chemistry research, enabling the development of novel pharmacologically active molecules. Pharmaceutical R&D teams and fine chemical manufacturers need it for creating new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• CNS Drug Development: Employed in the research of potential therapeutics targeting neurological disorders due to its piperazinone core.
• Oncology Research: Serves as a building block for novel kinase inhibitors and other targeted cancer therapies.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in bespoke chemical synthesis projects.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-4-Yl)-2-Piperazinone
CAS No.	1147422-83-0
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	1-(Oxan-4-yl)piperazin-2-one; 2-Piperazinone, 1-(tetrahydro-2H-pyran-4-yl)-; THP-Piperazinone; 1-(Tetrahydropyran-4-yl)-2-piperazinone; 1-(Tetrahydro-2H-pyran-4-yl)piperazin-2-one; 4-(2-Oxopiperazin-1-yl)tetrahydro-2H-pyran
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydro-2H-Pyran-4-Yl)-2-Piperazinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.