Description

n-(3-Chlorophenyl)-N'-[5-[2-(Thieno[3,2-D]Pyrimidin-4-Ylamino)Ethyl]-2-Thiazolyl]Urea Methanesulfonate (1:1) is a high-purity, non-salt-free reference standard and pharmaceutical intermediate of significant importance in modern drug discovery. This compound is specifically designed for research and development targeting protein kinase inhibition, offering a critical building block for novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology, immunology, and metabolic disease pathways.

Application

• Pharmaceutical Reference Standard: Serves as a certified material for analytical method development, validation, and quality control in drug substance and product testing.
• Kinase Inhibitor Research: A key intermediate in the synthesis and screening of novel small-molecule inhibitors targeting specific kinase enzymes implicated in disease.
• Preclinical Drug Development: Used in in vitro and in vivo studies to evaluate pharmacokinetics, pharmacodynamics, and initial efficacy of candidate drug molecules.
• Chemical Biology Probes: Employed in mechanistic studies to understand cellular signaling pathways and protein function.
• Process Chemistry & Scale-Up: Acts as a critical intermediate during the optimization and pilot-scale synthesis of active pharmaceutical ingredients (APIs).
• Academic Research: Supports fundamental research in medicinal chemistry and biochemistry at universities and research institutes.

Basic Information

Product Name	n-(3-Chlorophenyl)-N'-[5-[2-(Thieno[3,2-D]Pyrimidin-4-Ylamino)Ethyl]-2-Thiazolyl]Urea Methanesulfonate (1:1)
CAS No.	1146618-41-8
Molecular Formula	C19H17ClN6O2S2 • CH4O3S
Molecular Weight	Contact for details
Synonyms	N-(3-Chlorophenyl)-N'-[5-[2-[(Thieno[3,2-d]pyrimidin-4-yl)amino]ethyl]-1,3-thiazol-2-yl]urea methanesulfonate; UNII-9Q3V4Q2Q8S; 9Q3V4Q2Q8S; Thieno[3,2-d]pyrimidine-4-amine, N-[2-[5-[[[(3-chlorophenyl)amino]carbonyl]amino]-2-thiazolyl]ethyl]-, methanesulfonate (1:1); Urea, N-(3-chlorophenyl)-N'-[5-[2-[(thieno[3,2-d]pyrimidin-4-yl)amino]ethyl]-2-thiazolyl]-, methanesulfonate (1:1).
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. For this advanced intermediate, quality is assured through stringent analytical controls including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We adhere to ISO 9001 quality management principles, and production can be aligned with GMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.