Description

1-Isobutyl-1,2,3,4-Tetrahydropyrrolo-[1,2-A]Pyrazine CAS NO 1146299-06-0 is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry, process R&D, and the production of high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) and other specialized therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing novel chemical libraries in drug discovery programs, enabling structure-activity relationship (SAR) studies.
• Process Development & Scale-up: Used in optimizing synthetic routes from laboratory scale to pilot plant and commercial manufacturing for new APIs.
• Contract Manufacturing (CMO/CDMO): Supplied to contract development and manufacturing organizations for the production of clinical trial materials and commercial drug substances.
• Academic Research: Employed in university and institutional labs for studying heterocyclic chemistry, reaction mechanisms, and the development of new synthetic methodologies.
• Specialty Fine Chemicals: A building block for synthesizing other high-value, complex molecules used in agrochemicals or advanced material science.

Basic Information

Product Name	1-Isobutyl-1,2,3,4-Tetrahydropyrrolo-[1,2-A]Pyrazine
CAS No.	1146299-06-0
Molecular Formula	C12H20N2
Molecular Weight	192.30 g/mol
Synonyms	1-Isobutyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; Pyrrolo[1,2-a]pyrazine, 1,2,3,4-tetrahydro-1-(2-methylpropyl)-; 1-(2-Methylpropyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine; 1146299-06-0; UNII-9K1U4P8T4Q; 9K1U4P8T4Q
EINECS	Contact for details

Quality Control

Our 1-Isobutyl-1,2,3,4-Tetrahydropyrrolo-[1,2-A]Pyrazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable, and specifications can be aligned with client requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0% Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.