Description

tert-Butyl 4-[(2,2,2-Trifluoroethyl)Amino]Piperidine-1-Carboxylate is a high-purity, protected piperidine derivative featuring a trifluoroethylamino substituent. This compound matters as a critical pharmaceutical intermediate and building block for medicinal chemistry research, enabling the synthesis of novel bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the trifluoroethylamino-piperidine pharmacophore.
• Protease Inhibitor Synthesis: Serves as a precursor for inhibitors targeting various proteases, where the piperidine scaffold is a common structural element.
• Agrochemical Active Ingredient Development: Employed in the research and synthesis of novel herbicides, fungicides, or insecticides.
• Ligand for Catalysis: Potential use in the development of chiral ligands or organocatalysts for asymmetric synthesis.
• Chemical Biology Probe Synthesis: Useful for creating tool compounds to study biological pathways and protein function.

Basic Information

Product Name	tert-Butyl 4-[(2,2,2-Trifluoroethyl)Amino]Piperidine-1-Carboxylate
CAS No.	1146289-88-4
Molecular Formula	C12H21F3N2O2
Molecular Weight	282.30 g/mol
Synonyms	1-Boc-4-[(2,2,2-trifluoroethyl)amino]piperidine; 4-[(2,2,2-Trifluoroethyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-[(2,2,2-trifluoroethyl)amino]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[(2,2,2-trifluoroethyl)amino]piperidine; N-(2,2,2-Trifluoroethyl)-4-amino-1-Boc-piperidine; 4-(2,2,2-Trifluoroethylamino)piperidine-1-carboxylic acid tert-butyl ester; 1-Boc-4-(2,2,2-trifluoroethylamino)piperidine; Boc-4-(2,2,2-trifluoroethylamino)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(2,2,2-Trifluoroethyl)Amino]Piperidine-1-Carboxylate is manufactured under cGMP-compliant conditions where applicable, ensuring traceability and batch-to-batch consistency. All products undergo rigorous quality testing via HPLC, NMR, and MS to verify identity, purity, and impurity profiles. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.