Description

4-[2-(3-Chloro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. This compound serves as a critical building block in the development of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and receptor-targeting therapeutics. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the synthesis of novel drug candidates and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug molecules, particularly those targeting neurological pathways.
• API Synthesis: Used in the research and development of new Active Pharmaceutical Ingredients (APIs), leveraging its piperazine and chiral alcohol functionalities.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: Employed by CDMOs for the contract manufacturing of bespoke organic compounds for clinical trials and commercial production.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	4-[2-(3-Chloro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1146080-16-1
Molecular Formula	C17H25ClN2O3
Molecular Weight	340.85 g/mol
Synonyms	tert-Butyl 4-[2-(3-chlorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate; 1-Boc-4-[2-(3-chlorophenyl)-2-hydroxyethyl]piperazine; 4-(2-(3-Chlorophenyl)-2-hydroxyethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[2-(3-chlorophenyl)-2-hydroxyethyl]piperazine; 1146080-16-1; 3-Chloro-α-[(1-(tert-butoxycarbonyl)piperazin-4-yl)]benzyl alcohol
EINECS	Contact for details

Quality Control

Our 4-[2-(3-Chloro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.