Description

4-[2-(4-Chloro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and other therapeutic areas. It is essential for research institutions and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Drug Discovery & Medicinal Chemistry: Used in research and development for constructing complex molecular scaffolds with potential biological activity.
• Chemical Synthesis Building Block: The piperazine and protected carboxylic acid functionalities make it valuable for creating diverse chemical libraries.
• Process Development & Scale-Up: Employed in optimizing synthetic routes from laboratory to pilot and commercial manufacturing scales.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	4-[2-(4-Chloro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1146080-12-7
Molecular Formula	C17H25ClN2O3
Molecular Weight	340.85 g/mol
Synonyms	tert-Butyl 4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate; 1-Boc-4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazine; 4-(2-(4-Chlorophenyl)-2-hydroxyethyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-4-(2-(4-chlorophenyl)-2-hydroxyethyl)piperazine; (4-Chlorophenyl)(1-(tert-butoxycarbonyl)piperazin-4-yl)methanol; 1,1-Dimethylethyl 4-[2-(4-chlorophenyl)-2-hydroxyethyl]-1-piperazinecarboxylate
EINECS	Contact for details

Quality Control

Our 4-[2-(4-Chloro-Phenyl)-2-Hydroxy-Ethyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full batch traceability are provided to guarantee compliance with your project specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.