Description

(S)-tert-Butyl 4-(tert-Butoxycarbonylamino)-4-(1-(4-Chlorophenyl)-3-Hydroxypropylcarbamoyl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly in the creation of novel therapeutic agents targeting the central nervous system and other specialized areas. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions engaged in drug discovery and process development.

Application

• Key Intermediate in API Synthesis: Serves as a crucial building block in the multi-step synthesis of complex drug candidates, particularly those with piperidine-based pharmacophores.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale production for clinical trial material manufacturing.
• Protease Inhibitor Research: Potential intermediate in the development of inhibitors for various enzymatic targets due to its specific stereochemistry and functional groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP conditions.

Basic Information

Product Name	(S)-tert-Butyl 4-(tert-Butoxycarbonylamino)-4-(1-(4-Chlorophenyl)-3-Hydroxypropylcarbamoyl)Piperidine-1-Carboxylate
CAS No.	1143534-57-9
Molecular Formula	C25H38ClN3O6
Molecular Weight	512.04 g/mol
Synonyms	1,1-Dimethylethyl N-[(3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[[4-(4-chlorophenyl)-3-hydroxybutyl]carbamoyl]-3-piperidinecarboxylate; (S)-1-Boc-4-[(N-Boc-amino)-4-[(1-(4-chlorophenyl)-3-hydroxypropyl)carbamoyl]]piperidine; tert-Butyl (3S)-3-[(tert-butoxycarbonyl)amino]-3-[[[4-(4-chlorophenyl)-3-hydroxybutyl]amino]carbonyl]-1-piperidinecarboxylate; 1143534-57-9; UNII-7V1B8Q8F0F
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We implement quality systems aligned with ICH Q7 guidelines and can supply material suitable for use under cGMP conditions for clinical manufacturing. Specifications are designed to meet the exacting requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.